Stargardts, Retinitis Pigmentosa, Age-related Macular Degeneration, Choroideremia, Geographic Atrophy
Conditions
Keywords
Retina, imaging, retinal degeneration
Brief summary
Studying the morphology and function of the normal and diseased retina in vivo is needed for advancing the detection, diagnosis, and treatment of retinal disease. This protocol uses an adaptive optics scanning laser ophthalmoscope (AOSLO) to image the normal and diseased retina with individual cellular resolution non-invasively. The primary objective of this study is to obtain and analyze high-resolution images of the retina, in particular by imaging the cone photoreceptor mosaic, the retinal vasculature and other retinal layers. The study design will involve case-control studies, where cases are followed over time. Subjects age 7 and older may be invited to participate. The main research procedure involves retinal imaging with the AOSLO. The primary endpoint is the observation of differences in retinal images between subjects with and without retinal diseases. These changes will be quantified by examining the cell density, size, spacing and regularity of the cone photoreceptor mosaic, as well as examining the differences between other retinal layers.
Interventions
PROCEDURERetinal imaging
Retinal imaging procedures include adaptive optics imaging, optical coherence tomography and fundus photography.
Sponsors
National Eye Institute (NEI)
University of Pennsylvania
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
7 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Males or females age 7 years or older. * Parental/guardian permission (informed consent) and if appropriate, child assent. Child subjects age 7-17 must give assent. * Reasonable compliance with an imaging protocol as determined by the study personnel.
Exclusion criteria
* Individuals that are at risk to acute glaucoma. * Individuals that are photophobic and experience adverse psychological reactions to flashes of light. * Ocular opacities, high refractive error, and high frequency of nystagmus as determined by the study team.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| high-resolution images of retina | 1 day (initial visit) | The primary objective of this study is to obtain and analyze high-resolution images of the retina in normal and diseased eyes non-invasively. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cone mosaic parameters | 1 day (initial visit) | Imaging the cone photoreceptor mosaic, and analyzing cell density, size, spacing, regularity, and other mosaic parameters in normal retina compared to diseased retina. |
Countries
United States
Contacts
Primary ContactJessica IW Morgan, PhD
Outcome results
None listed