Sleep, Meals
Conditions
Keywords
Sleep, Sleep duration, Meals, Food intake, Obesity
Brief summary
The purpose of this study is to test the effects of sleep and meal timing, independent of sleep duration, on glucose regulation and metabolic and hormonal control of energy balance in normal weight adults. This study will be a 4-phase, randomized controlled study of 5 days each in which participants will undergo 2 phases of late sleep times that differ in meal timing (normal or late) and 2 phases of normal sleep times that differ in meal timing (normal or late). The Aims and Hypotheses of this study are: Aim 1: To compare hormonal regulation of food intake and metabolic risk markers in response to altered sleep and meal timing. * Hypothesis 1: There will be an interaction between sleep and meal time on glucose, insulin, and glucose and insulin area under the curve after the glucose tolerance test such that the late sleep/late meal will result in the worst metabolic profile, normal sleep/late meal and late sleep/normal meal will have an intermediate profile, and normal sleep/normal meal will result in the best metabolic profile. * Hypothesis 2: There will be an interaction between sleep and meal time on leptin and ghrelin concentrations such that the late sleep/late meal timing phase will result in low leptin/high ghrelin, normal sleep/late meal timing and late sleep/normal meal will have an intermediate profile, and normal sleep/normal meal timing will result in high leptin/low ghrelin. Aim 2: To compare food intake over a 24-h period in response to altered sleep and meal timing. • Hypothesis 3: Energy and fat intakes will be greater during the late sleep timing phase compared to normal sleep timing.
Interventions
BEHAVIORALNormal sleep
Normal sleep= sleep 2300-0700
BEHAVIORALNormal meals
Normal meal times=approximately 1.5, 5, and 11 h after wake up for breakfast, lunch, and dinner, and snack at 13 h after wake up time
BEHAVIORALLate sleep
Late sleep=sleep at 0230-1030 hours
BEHAVIORALLate meals
Late meal times= approximately 4.5, 7, and 13 h after wake up time for breakfast, lunch and dinner, and snack at 15 h.
Sponsors
St. Luke's-Roosevelt Hospital Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Body mass index 22-25 * Normal scores on sleep questionnaires (PSQI, ESS, Berlin, SDIQ) * Normal score on Beck Depression Inventory * Intermediate chronotype on Composite Scale of Morningness/Eveningness
Exclusion criteria
* Neurological, medical, or psychiatric disorders * Eating disorders * Diabetes * Sleep disorders * Travel across time zones * History of drug/alcohol abuse * Caffeine intake \>300 mg/d * Excessive daytime sleepiness * Pregnancy or within 1 y post-partum
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Food intake | Single day | Ad libitum food intake will be assessed on day 5 |
| Oral Glucose Tolerance | 2 hours | Oral glucose tolerance test will be performed at scheduled breakfast time on day 4 |
| Meal tolerance test | 3 hours | Glucose and insulin responses to a liquid meal will be assessed at scheduled lunch time |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hormonal profile | 24 hours | On day 3, the following hormones will be assessed from overnight hours: glucose, insulin, cortisol, melatonin, leptin, ghrelin, PYY, GLP-1 |
Countries
United States
Outcome results
None listed