Impact of tDCS on Cerebral Autoregulation

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01865604

Enrollment

Registered

2013-05-31

Start date

2012-04-30

Completion date

2014-03-31

Last updated

2016-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral Microangiopathy, CADASIL, Migraine With Aura, ICA Stenosis

Brief summary

The aim of the study is to investigate whether there is a polarity-specific influence of tDCS on cerebral vasomotor reactivity monitored by transcranial doppler sonography.

Interventions

DEVICEAnodal tDCS

DEVICECathodal tDCS

DEVICEsham tDCS

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

1. severe cerebral Microangiopathy 2. NOTCH3 carrier 3. Migraine with aura (IHS Classification ICHD-II) 4. Stenosis \>80%, ECST-Criteria

Exclusion criteria

* seizure disorder * history of severe alcohol or drug abuse, psychiatric illness like severe depression, poor motivational capacity * dementia (1+2) history of stroke in past 3 months (3) migraine prophylaxis (4) contralateral stenosis \>50%,

Design outcomes

Primary

Measure	Time frame	Description
Cerebral vasomotor reactivity assessed by transcranial Dopplersonography	on 3 days within 12 weeks	comparing cerebral vasomotor reactivity at baseline and after anodal/cathodal/sham stimulation

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026