IN UTERO SMOKING AND PREMATURE CELLULAR SENESCENCE

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01865435

Enrollment

Registered

2013-05-30

Start date

2014-03-31

Completion date

2015-04-30

Last updated

2015-10-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease

Brief summary

Actually, there is an increasing number of arguments for a premature origin of chronic adult's diseases, as the chronic obstructive pulmonary disease (COPD). Several factors interacting with the foetal or postnatal lung growth are associated with early and long-lasting respiratory functional changes susceptible to contribute very significantly to the arisen of a COPD in the adulthood. It is possible that these situations reflect phenomena of premature cellular senescence, recently involved in the physiopathology of the COPD. An in utero exposition to cigarette smoking is one of these situations, because it is known to induce, not only functional respiratory changes, but also multiple diseases in the child which could testify of cellular ageing phenomena. Our project aims to demonstrate that in utero smoking is associated with markers of premature cellular senescence in newborn children The study will be driven in human newborn child's, with comparison of the length of the telomeres in circulating lymphocytes (umbilical blood is collected), according to the exposure in in utero smoking and also according to the degree of hypotrophy. This study will be a pilot study completed by an animal experimental study.

Interventions

GENETICcord blood sample

Study design

Allocation

Intervention model

SINGLE_GROUP

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

No minimum to 27 Days

Healthy volunteers

Inclusion criteria

* Born weight upper or equal to the 10th percentile and absence of smoking declared by the mother * Born weight lower than the 10th percentile and absence of smoking declared by the mother * Born weight upper or equal to the 10th percentile and smoking declared by the mother of at least 5 cigarettes a day * Born weight lower than the 10th percentile and smoking declared by the mother of at least 5 cigarettes a day

Exclusion criteria

* Gestationnel age 37 LIMITED COMPANIES * Low(Weak) declaratory(declarative) maternal smoking (1 in 4 cigarettes a day) * Pathologies associated by the newborn child (deformations, foetal suffering, infection maternofœtale, respiratory distress syndrome)

Design outcomes

Primary

Measure	Time frame
cord blood samples	12months

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026