the Influence of Tidal Volume to Lung Strain

the Influence of Different Tidal Volume to Lung Strain of ARDS Patients

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01864668

Enrollment

Registered

2013-05-29

Start date

2013-06-30

Completion date

2014-03-31

Last updated

2014-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Respiratory Distress Syndrome, Critically Ill

Keywords

Acute respiratory distress syndrome, lung strain, small tidal volume

Brief summary

Measure the lung strain in different tidal volume in ADRS patients to find the relationship between tidal volume and lung strain and find the most suitable tidal volume for each patient.

Detailed description

Purpose:Find the relationship between tidal volume and lung strain in ARDS patients.Then find the most suitable tidal volume for each patient according to the dividing value. Methods:Measure the lung strain in the tidal volume of 6mL/kg,8mL/kg,10mL/kg and 12mL/kg in each ARDS patient. Hypothesis:With the increase of the tidal volume,the lung strain develops.In the patient with larger lung compliance,the strain of the group of conventional tidal volume is less than 0.27 and there is no obvious difference between the group of small tidal volume.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

1. Age:18-85,gender is not limited 2. Needing Invasive ventilation 3. Fit the definition of ARDS in 2012 Berlin Definition 4. Sign the paper of informed consent

Exclusion criteria

1. pregnancy and at the end stage of tumour 2. the COPD patients 3. less than 24h of mechanical ventilation 4. more than 5 days of mechanical ventilation 5. FiO2\>80% 6. presence of air leaks 7. organ dysfunction and hemodynamic instability 8. including in other research

Design outcomes

Primary

Measure	Time frame	Description
the strain in different tidal volume	2 hours	Use the GE ventilator to measure the EELV and calculate the lung strain(lung strain = VT/EELV)

Secondary

Measure	Time frame	Description
28 days mortality	28 days	Follow up to determine the mortality in 28 days after inclusion

Countries

China

Contacts

Primary ContactXiaohua Qiu, MD

xiaohua0917@163.com0086-025-83262553

Backup ContactFang Jin, MD

doris_king@163.com0086-15850601638

Outcome results