Achalasia
Conditions
Keywords
Achalasia, Hot water drinking therapy, Pneumatic dilation
Brief summary
From clinical observation that some achalasia patients drink water to help swallow food, the investigators have proposed a systemic hot water drinking therapy. This study is to observe its efficacy on achalasia symptoms and explore its mechanism.
Detailed description
1. Achalasia patients will participate hot water drinking therapy: to drink 200ml of hot water before and after a meal, as well as 2 hours before sleep and to chew food carefully and swallow with hot soup. 2. Patients are followed by achalasia associated symptom scores, barium esophagram and endoscopy. 3. If patients are unsatisfied with hot water drinking therapy, they receive pneumatic dilation
Interventions
OTHERhot water drinking therapy
Drink 200ml hot water 3min before and after a meal. Swallow food with hot water and drink 200ml hot water before sleep
PROCEDUREPneumatic dilation
Patients who are unsatisfied with hot water drinking therapy are to receive standard pneumatic dilation under endoscope
Sponsors
Peking Union Medical College Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* achalasia patients diagnosed by endoscopy, barium esophagram and manometry
Exclusion criteria
* could not drink water * poor compliance * severe comorbidities * esophageal stenosis secondary to erosions and cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline achalasia symptom score at 1 month | baseline and 1 month | Dysphagia, Regurgitation and Chest Pain scores |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in barium esophagram at 1 year | baseline and 1 year | measure esophageal diameter |
| Endoscopy at 1 year | year 1 | esophageal bezoars and esophageal cancer |
| Pneumatic dilation rate and relative efficacy | any time | Patients who are unsatisfied with hot water drinking therapy are to receive pneumatic dilation |
| Number of patients with adverse effects | Week 1 | adverse effects of drinking water like distention, nausea and belching |
| Change from baseline achalasia symptom scores at 5 years | baseline and 5 years | Dysphagia,Regurgitation and Chest Pain scores |
| Change from baseline in barium esophagram at 5 years | baseline and 5 years | measure esophageal diameter |
| Endoscopy at 5 years | year 5 | esophageal bezoars and esophageal cancer |
| Change from baseline in achalasia symptom score at 1 year | baseline and 1 year | Dysphagia,Regurgitation and Chest Pain scores |
Countries
China
Contacts
Primary ContactYutang Ren, M.D.
Outcome results
None listed