Post Partum Hemorrhage
Conditions
Keywords
Misoprostol, Oxytocin, Post Partum Hemorrhage (PPH), Third stage of labour
Brief summary
Post partum Hemorrhage (PPH) is one of three main causes of death in pregnant women. Oxytocin is widely used for prevention of PPH. Some studies suggested misoprostol as an alternative treatment when Oxytocin isn't available. The aim of this study is to compare the safety and efficacy of Oxytocin and misoprostol for prevention of PPH.
Detailed description
In a double blind randomized controlled trial 400 pregnant women who has vaginal delivery at Shariati hospital are assigned into two groups either to receive 20 unite oxytocin in 1000cc ringer and 2 placebo tablet or 400mcg oral misoprostol and 2cc normal saline in 1000cc ringer.
Interventions
DRUGMisoprostol
400µg oral misoprostol
DRUGOxytocin
20 IU Oxytocin
Sponsors
Hormozgan University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
10 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* were women with singleton pregnancy * with cephalic presentation * who had NVD spontaneously or by induction
Exclusion criteria
* placenta previa * placental detachment * coagulation problems * previous CS * macrosomia * Polyhydramnios * and uncontrolled asthma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Amount of bleeding | 1 hour | within 1 hours after delivery |
Secondary
| Measure | Time frame |
|---|---|
| Hemoglobin decrease | 24 hours |
| Hematocrite decrease | 24 hours |
Other
| Measure | Time frame | Description |
|---|---|---|
| Side effects | 24 hours | Diarrhea, Vommiting, Fever, Chills |
Countries
Iran
Outcome results
None listed