Arterial Remodeling in Smokers

Response-to-injury in Patients Undergoing Transradial Coronary Angiography: Arterial Remodeling in Smokers

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01862146

Acronym

TCA

Enrollment

Registered

2013-05-24

Start date

2013-04-30

Completion date

2014-06-30

Last updated

2014-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

FMD, IMT, Smoking

Keywords

TCA, FMD, IMT, Smoking

Brief summary

Cigarette smoking is the most important modifiable cardiovascular risk factor leading to endothelial dysfunction and was suggested to impair arterial regeneration.The aim of the study was to investigate the effect of smoking on vascular response to transradial coronary angiography (TCA).

Interventions

PROCEDUREsmoke expose

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* all subjects underwent a TCA

Exclusion criteria

* acute inflammation cardiac arrhythmia renal failure heart failure (NYHA II-IV) CRP \> 1 mg/dl malignant disease

Design outcomes

Primary

Measure	Time frame	Description
IMT hyperplasia	change in radials IMT after 6-14 month after a TCA	IMT is measured by high resolution ultrasound in the radial arteries.

Secondary

Measure	Time frame	Description
Endothelial function	change in flow mediated dilatation after 10-14 months	Flow mediated dilatation (FMD)

Other

Measure	Time frame	Description
cell migration	baseline	measured by boyden chamber from blood plasma
Regeneration	baseline	measured by scratch assay

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026