Liver Metastases
Conditions
Keywords
liver function, galactose, 18-F-deoxy-galactose
Brief summary
Background: Anatomical (traditional) stereotactic body radio therapy(SBRT) treatment planning assumes homogenous distribution of function in the normal liver tissue. In functional treatment planning, additional information on distribution of the function derived from functional imaging of normal tissue is taken into account. by functional treatment planning it becomes possible to prioritize and spare the best functioning part of an organ. Aim: To test whether functional treatment planning based on 18-FDGal PET/CT may spare the best functioning liver tissue. Endpoints: Reduction in hepatic systemic clearance (K) in the dynamic 18-FDGal PET/CT scan one month after SBRT compared to the baseline status in sub-volumes recieving 15 Gy or higher. Secondly, the investigators will evaluate the toxicity to SBRT by a toxicity scoring system that includes biochemical measures as well as symptomatic scores.
Interventions
OTHERmeasuring liver function by 18-FDGal PET/CT
Sponsors
Danish Cancer Society
University of Aarhus
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Performance status \>2 * liver metastases refereed for SBRT
Exclusion criteria
* pregnancy * claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| volumetric uptake values of 18-FDGal will be measured and the 18-FDGal PET/CT one month after stereotactic body radioation therapy will be compared to the baseline status in sub-volumes receiving more than 15 Gy | up to 2 years |
Secondary
| Measure | Time frame |
|---|---|
| evaluate toxicity to SBRT by toxicity scoring system that includes biochemical measures as well as symptomatic scores. | up to 2 years |
Countries
Denmark
Outcome results
None listed