Spinal Cord Injuries
Conditions
Keywords
Spinal Cord Injuries, Cerebrospinal Fluid
Brief summary
The project is aimed to develop predictive indices of spinal cord injury severity through the analysis of cerebrospinal fluid of patient collected during acute injury.
Interventions
OTHERLumbar puncture
The only intervention is the lumbar puncture on the patients to obtain a Cerebrospinal Fluid sample
Sponsors
Azienda Usl di Bologna
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* presence of cervical and thoracic Spinal Cord Injury * need to be submitted to spine surgical stabilization with posterior approach
Exclusion criteria
* prior to recruitment, in the acute phase, treatment with steroid therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Creation of a model which analyze relationship among laboratory investigations and primary lesion, secondary damage and functional impairment | Three years | Correlation of the dosage of more than 20 tentative biomarkers with the biological effect of Cerebrospinal Fluid exposure on human cell lines, in order to directly test those effects. The Cerebrospinal Fluid will be encoded using technical procedures, divided into aliquots, quickly frozen and stored at 80°C. Biomarkers will be measured in the Cerebrospinal Fluid, related to: * inflammatory and vascular reaction, by a cytokine panel including 12 different cytokines/chemochines; * neurodegeneration and excitotoxicity, by a panel of 10 different biomarkers. |
Countries
Italy
Outcome results
None listed