Cystitis, Pyelonephritis, Urinary Tract Infection
Conditions
Brief summary
Cranberry and cranberry-lingonberry juice prevented urinary tract infections in children and in adults in our earlier clinical trials. The preventive effect was, however, observed late in the follow-up and the next recurrence was not prevented in children. The investigators hypothesize that cranberry-lingonberry juice should be started already during the antimicrobial treatment of acute urinary tract infection in order to maximize the preventive efficacy of the juice. In addition, the investigators aim to find the explanation for the efficacy of cranberry-lingonberry juice by analyzing the concomitant changes in the chemical composition of urine and feces as well as the changes of gut microbiota.
Interventions
OTHERCranberry-lingonberry juice
OTHERPlacebo juice
Juice iwth similar sugar concentration as cranberry-lingonberry juice but without berry extracts
Sponsors
University of Oulu
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
1 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
* Recent confirmed urinary tract infection, diagnosed in Oulu University Hospital or Oulu Health Care Center * Age 1-16 years
Exclusion criteria
* Continuous antimicrobial prophylaxis * Age \< 12 months or \> 16 years * Severe congenital kidney or other urinary tract anomaly in ultrasound
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of the intestinal and urinary microbiome | 3 months to 12 months |
Secondary
| Measure | Time frame |
|---|---|
| The occurrence of urinary tract infections (infection episodes/person years at risk) | 12 months |
| Time to the first recurrence | 6 months |
Countries
Finland
Outcome results
None listed