Hypertension
Conditions
Keywords
target organ damage, incident hypertension, cohort
Brief summary
The objective of this study is to know prevalence of clinical or subclinical target organ damages in Korea hypertensives by constructing nationwide hypertension registry. We will register 5000 consecutive patients with incident hypertension at 20 major university hospitals in South Korea. We will investigate clinical/subclinical target organ damages, renin/aldosterone level and cardiovascular events in each patient.
Detailed description
Background: the exact prevalence of target organ damages in Korean hypertensives are unknown. Study Objective: to investigate the prevalence of target organ damages in Korean patients with incident hypertension. Study Design: prospective, multi-center and observational study Study Populaton: approximately 5000 consecutive patients with incident hypertension, who visited outpatients clinics and agreed to participate in the registry Primary outcome * Subclinical organ damages 1. left ventricular hypertrophy on electrocardiogram or echocardiography 2. increased intima media thickness of carotid artery (\> 0.9 mm) or plaque 3. increased pulse wave velocity (\> 12 m/s) 4. low estimated glomerular filtration rate (\< 60 ml/min/1.73 m2) or creatinine clearance (\<60 ml/min) * Established CV or renal disease 1. cerebrovascular disease: ischemic stroke; cerebral stroke; transient ischemic attack 2. Heart disease: myocardial infarction; angina; coronary revascularization; heart failure 3. Renal disease: diabetic retinopathy; serum creatinine M \> 133, W \> 124 mmol/L; proteinuria \> 300 mg/24 hr 4. Peripheral artery disease 5. Advanced retinopathy: hemorrhage or exudates, papilledema
Interventions
None listed
Sponsors
Dongtan Sacred Heart Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age≧30years * primary incident hypertension * singed informed consent
Exclusion criteria
* participated in other clinical trials
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| left ventricular hypertrophy | at enrollment | left ventricular hypertrophy on electrocardiogram or echocardiography Sokolow-Lyon \> 38 mm; left ventricular mass index male \>= 125 g/m2, female \>=110 g/m2) |
| Intima media thickness of carotid artery | at enrollment | increased intima media thickness of carotid artery (\> 0.9 mm) or presence of plaque |
| pulse wave velocity | at enrollment | increased pulse wave velocity (\> 12 m/s) |
| kidney function | at enrollment | low estimated glomerular filtration rate (\< 60 ml/min/1.73 m2) or creatinine clearance (\< 60 ml/min) |
| cerebrovascular accident | at enrollment | ischemic stroke, cerebral hemorrhage, or transient ischemic attack confirmed by a neurologist |
| renal disease | at enrollment | serum creatinine male \> 1.5 mg/dl, female \> 1.4 mg/dl; proteinuria \> 300 mg/24hr |
| peripheral artery disease | at enrollment | ankle to brachial blood pressure ratio \< 0.9 |
| retinopathy | at enrollment | retinal hemorrhage or exudate, papilledema confirmed by an ophthalmologist |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hypertension | at enrollment | high blood pressure confirmed by ambulatory blood pressure monitoring (24hr average systolic blood pressure \>=135 mm Hg, diastolic blood pressure \>= 85 mm Hg |
| Dyslipidemia | at enrollment | total cholesterol 190 mg/dl or LDL \> 115 mg/dl, HDL male \< 40 mg/dl, female \< 46 mg/dl or triglyceride \> 150 mg/dl |
| abnormal fasting plasma glucose | at enrollment | abnormal fasting plasma glucose (102-125 mg/dl) |
| abdominal obesity | at enrollment | waist circumference male \> 102 cm, female \> 88 cm |
| diabetes mellitus | at enrollment | fasting plasma glucose \>= 126 mg/dl; postload plasma glucose \> 198 mg/dl |
Countries
South Korea
Contacts
PRINCIPAL_INVESTIGATORKyu-Hyung Ryu, MD, PhD
Dongtan Sacred Heart Hospital, Hallym University
Outcome results
None listed