Cholangiocarcinoma
Conditions
Keywords
bili duct neoplasms, bile duct cancer, photodynamic therapy, biliary drainage
Brief summary
This research is a prospective randomized controlled trial.It aimed to determine longterm outcomes and factors associated with increased survival after photodynamic therapy (PDT) through T-tube compared with biliary drainage alone in patients presenting with unresectable bile duct cancer.
Interventions
PROCEDUREPhotodynamic therapy
Each patient to whom PDT was offered underwent a specific, detailed educational process by a dedicated team member(P.B., P.J., or K.E.), after which informed consent was obtained.Porfimer sodium (Photofrin; Axcan Pharma Inc, Quebec, Canada)was used as a photo sensitizing agent, administered intravenously at a dose of 2 mg/kg body weight 48 hours before illumination.A diode laser system (InGaAIP Laser Diode; Diomed Inc, An-dover, MA) with a maximum power output of 2000 mW and a wavelength of 633+-3 nm was used as a light source, delivered through a 3.0-m length fiber having a 2.5-cm-long cylindrical diffuser at its distal end (Pioneer Optics, Windsor Locks, CT).
Sponsors
li xiong
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* 1.Patients with bile duct cancer 2.Patients are willing to join in this clinical trial.
Exclusion criteria
* 1.Patients with bile duct carcinoma can not suffer PDT procedure. 2.Allergy to photosensitizer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival rate | one month |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life | one month |
Other
| Measure | Time frame |
|---|---|
| Complication of therapy | one month |
Countries
China
Outcome results
None listed