Type 2 Diabetes Mellitus
Conditions
Keywords
hypoglycemia, GLP-1, Type 2 diabetes, endothelial function
Brief summary
Low blood sugar can negatively affect how blood vessels function, and this can lead to an increase in the risk for heart attacks, strokes and other problems related to the stiffening and blockage of blood vessels. The purpose of this study is to learn if and how glucagon-like peptide-1 (GLP-1; a naturally occurring hormone in the gut) changes the effects that low blood sugar levels have on blood vessels.
Interventions
DRUGGlucagon-Like Peptide- 1 (GLP-1) infusion
GLP-1 infusion during experimental period
OTHERPlacebo Comparator: Saline Infusion
Saline infusion (placebo) during experimental period
Sponsors
University of Maryland, Baltimore
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* 14 (7 males, 7 females) healthy controls age 30-60 yr. * 14 (7 males, 7 females) people with type 2 DM age 30-60 yr. * For type 2 DM: HbA1c 6-10.0% * No significant diabetic tissue complications (i.e. history of retinopathy, neuropathy, stasis ulcers, etc.) * Body mass index \>25kg • m-2
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Plasminogen Activation inhibitor-1 (PAi-1) | change from baseline to end of clamp period | measurements of change in PAi-1 at baseline and during the end of the glucose clamp period (2 hours) |
| Change in Flow mediated dilation (FMD) | change from baseline and end of clamp | flow mediated dilation of the brachial artery will be measured for change from baseline and end of glucose clamp (\ 4 hours) |
Countries
United States
Outcome results
None listed