Biomarkers Correlation With Volemia

Predictive Value of Biomarkers on Volemia, Extra and Intra Vascular Varation and Hydroelectrolytic Disorders in Different ICU Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01858675

Acronym

ENVOL

Enrollment

Registered

2013-05-21

Start date

2012-03-31

Completion date

2014-12-31

Last updated

2014-12-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral Hemorrhage, Head Injury, Non Traumatic Post Surgery, Poly Trauma Patients Without Heart Failure, Renal Insufficiency

Keywords

ProADM, ProANP, proendothelin, proAVP, Cr 51, Volemia, fluid management, ICU patients, poly trauma patients

Brief summary

The purpose of this study is to determine whether the Biomarkers (pro adrenomedullin (MR proADM), pro arginin vasopressin (CT proAVP), pro atrial natriuretic peptid (MR proANP), Pro Endothelin) changes at Day 2, Day 5 and Day 7 of ICU admission are correlated with Intravascular volume assessed by Cr 51 on red blood cells (Day 2 and Day 7) and by I 125 on albumine Day 7. The correlation of these Biomarkers are also evaluted with other markers such as erythropoietin and catecholamines. 80 ICU patients are included.

Interventions

OTHERBiomarkers, red blood cells and plasma assessment

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* 20 Cerebral Hemorrhage * 20 Head Injury * 20 post surgery non traumatic non neuro * 20 Polytrauma patients

Exclusion criteria

* Heart failure NYHA III or IV * Renal insufficiency creatinin clearance \< 30 ml/mn * age \< 18 Y * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Predictive value of biomarkers changes in Volemia variation	at Day 2, Day 5 and Day 7 of ICU admission	Correlation with total blood volume(assessed by Cr 51) and biomarkers(Mr proADM, Mr proANP, CT proAVP and proendothelin)changes

Secondary

Measure	Time frame	Description
Predictive value of biomarkers changes with efficient volemia, fluid managements and other Markers such erythropoietin	at Day 2, Day 5 and Day 7 of ICU admission	Correlation with efficient volemia and Biomarkers ( Mr proADM, Mr proANP, CT proAVP and proendothelin)changes.
Predictive value of Biomarkers with APACHE II and SOFA score and Prognosis at ICU discharge	at Day 2 , Day 5 and Day 7 of ICU admission and at discharge	Correlation of Biomarkers changes with APACHE II and SOFA score and Mortality at Day 2, Day 5 and Day 7 of their ICU admission and at ICU discharge.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 28, 2026