Insulin Resistance, Type 2 Diabetes
Conditions
Keywords
omega-3 fatty acids, randomized controlled trial
Brief summary
This study is to examine the change of fasting insulin, glucose, insulin sensitivity and related traits in response to the six month treatment of omega-3 fatty acids, including fish oil and flaxseed oil, in Chinese type 2 diabetic patients. Corn oil, rich in omega-6 fatty acids, will be selected as a controlled oil. The investigators hypothesize that omega-3 fatty acids could improve insulin sensitivity and glucose metabolism in Chinese type 2 diabetic patients.
Detailed description
The insulin resistance will be estimated by a homeostatic model assessment model of insulin resistance (HOMA-IR)
Interventions
DIETARY_SUPPLEMENTFish Oil Supplementation
DIETARY_SUPPLEMENTFlaxseed Oil Supplementation
DIETARY_SUPPLEMENTplacebo
Sponsors
National Natural Science Foundation of China
Zhejiang University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
35 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Fasting glucose \> 7.0 or have diabetes medication; 2. Male, 35-80 years; female, postmenopausal to 80 years; 3. Agree to participant in the trial.
Exclusion criteria
1. Deny to sign the informed consent; 2. type 1 diabetes; 3. Family history of hypertriglyceridemia or fasting triglyceride\>4.56 mmol/L; 4. Have severe liver disease, kidney disease or cancer; 5. Participating in the other clinical trial within 30 days; 6. Other diseases or conditions, for which the doctor of the patients do not agree his or her participating.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| insulin resistance | 180 days |
Countries
China
Outcome results
None listed