Gastric Cancer
Conditions
Keywords
dexmedetomidine, heart rate variability, preemptive epidural, gastrectomy
Brief summary
The use of epidural dexmedetomidine decreases the anaesthetic requirements and improved postoperative pain. Dexmedetomidine is a potent and highly selective a2-adrenoceptor agonist and has sympatholytic effect. Power spectral analysis of heart rate variability(HRV) is a useful tool to assess cardiac autonomic activity. We investigated whether preemptive epidural dexmedetomidine can develop hemodynamic change and it could be identify patients by HRV.
Interventions
DRUGpreemptive dexmedetomidine epidural bolus injection(1.5 mcg/kg)
Patients in the pre-emptive groups recived a dose of 1.5㎍/kg dexmedetomidine dissolved into normal saline 10cc before the induction of
DRUGnormal saline
patients in the control groups received the equivalent volume of normal saline.
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Patients consented to spinal anesthesia were enrolled * Patients aged 40\ 70 years olds undergoing gastrectomy * No contraindication of epidural analgesia * ASA class I and II * Patients consented to epidural anesthesia were enrolled
Exclusion criteria
* Patients with hypovolemia, coagulation disorders, local infection at the site of operation, history of headache, heart diseases, and history of allergy, chronic alcohol use or abuse, anemia, congenital heart diseases, bundle block, congestive heart failure or arrythmias * patients who had recently received sedative drugs or were under antidepressant treatment were not included in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate variability analysis | 5min perioids after fluid resuscitation. | Heart rate variability analysis was performed according to the Task Force recommendations. Frequency domain analysis was based on fast Fourier transformation. Power spectrum densities were calculated for low frequencies (LF: 0.04-0.15 Hz) and high frequencies (HF: 0.15-0.4 Hz) informalized units, defined as the LF or HF proportional part of the total power. Baseline and 30min after the injection of the study drug. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Epidural injection | at 30 min after the epidural injection of the study drug | And secondary data collection was done at 30 min after the epidural injection of the study drug. All of the HRV analysis was done before anaesthesia induction. |
Countries
South Korea
Outcome results
None listed