Assessment of International Normalized Ratio (INR) Prolongation in Patients Treated Simultaneously With Warfarin and Cephalosporins

Assessment of INR Prolongation in Patients Treated Simultaneously With Warfarin and Antibiotics From the Cephalosporins Family,Observational Retrospective Study.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01857050

Enrollment

236

Registered

2013-05-20

Start date

2013-04-30

Completion date

2014-01-31

Last updated

2014-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation, Pulmonary Embolism, Venous Thrombosis

Brief summary

Many drug interactions with Warfarin are well documented in the literature, including interactions with a variety of antibiotics. However,in mamy cases it is difficult to predict when the interaction remains theoretical and when it becomes clinically significant and will be reflected in the individual patient. This study's aim is to identify and characterize related conditions (including comorbidities, laboratory test results and other parameters related to the patient)that might be predictors for drug interactions turning from theoretical to clinically significant.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients aged 18 and over * Patients treated with a combination of Warfarin and Cephalosporins * Patients who were hospitalized in the department of internal medicine * Patients who were treated with Warfarin without Cefalosporins

Exclusion criteria

* Patients on Warfarin who did not actually receive the drug during their hospitalization * Patients whose medical records were not accessible or didn't contain full data

Design outcomes

Primary

Measure	Time frame
Reasons for INR prolongation in patients who were treated with the combination of Warfarin and Cephalosporins	Participants will be followed for the duration of thei hospital stay, an expected average of 7 days

Outcome results