Stability and Balance in Locomotion Through Exercise

Sensorimotor Treadmill Training to Improve Gait and Balance in Parkinson's Disease

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01856244

Acronym

StaBLE

Enrollment

Registered

2013-05-17

Start date

2013-06-30

Completion date

2016-06-30

Last updated

2016-10-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's Disease

Keywords

Parkinson's Disease, treadmill training, gait, balance, mobility

Brief summary

Persons with Morbus Parkinson commonly develop gait and balance disorders leading to dependence, loss of mobility and a high risk of falling. This study investigates the effectiveness of a sensorimotor treadmill intervention to improve walking and balance abilities in persons with early stages of Parkinson's disease. The sensorimotor treadmill training is conducted on a special treadmill device which is challenging the participants by small oscillations. This intervention, which is supposed to simulate walking on natural, uneven surfaces, is compared to a conventional treadmill training. Hypothesis: Sensorimotor treadmill training leads to larger improvements in walking and balance abilities as compared to conventional treadmill exercise.

Interventions

BEHAVIORALtreadmill walking

DEVICETreadmill

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Parkinson's disease stage 1-3 Hoehn and Yahr * United Parkinson Disease Rating Scale (UPDRS) 'gait' or 'postural stability' subscore of 1 or more * Ability to stand unaided and walk without an assistive device * Stable medication during the study period

Exclusion criteria

* On-off and wearing-off phenomena * Unstable medical or psychiatric illness * Clinically relevant cardiovascular or orthopaedic disease * Severe polyneuropathy * Cognitive impairment

Design outcomes

Primary

Measure	Time frame	Description
Change from Baseline Gait Speed	8 weeks and 20 weeks	Self selected walking speed is assessed on a 10 meter walk distance
Change from Baseline Balance	8 weeks and 20 weeks	Mini - Balance Evaluation Systems Test (Mini - BESTest), Postural Sway in the Romberg Test with eyes open and eyes closed for 30 seconds

Secondary

Measure	Time frame	Description
Change from Baseline Gait Performance	8 weeks and 20 weeks	Two Minute Walk Test (2MWT), Timed up-and-go Test, Assessment of tempo-spatial gait parameters
Change from Baseline Mobility	8 weeks and 20 weeks	Rivermead Mobility Index
Change from Baseline Unified Parkinson's Disease Rating Scale (UPDRS)	8 weeks and 20 weeks	—

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026