Bronchiectasis
Conditions
Keywords
Airway clearance techniques, Mucus clearance, Chest physiotherapy, Autogenic drainage, Slow expiration with glottis opened in lateral posture(ELTGOL), Temporary-positive expiratory pressure (T-PEP), Non cystic fibrosis bronchiectasis
Brief summary
Study design: a randomized, crossover trial. Each patient performed three different airway clearance techniques (Autogenic drainage, slow expiratory with glottis opened in lateral posture \[ELTGOL\], temporary- positive expiratory pressure \[T-PEP\] with not similar autonomy degree in a randomized order. Each technique were applied in 3 sessions during one week at alternate days (Monday /Wednesday/Friday or Tuesday/Thursday/Saturday). The time spent in each bronchial session was 40 minutes. Seven days were the wash-out time period between the different techniques.
Interventions
OTHERAutogenic drainage
It was performed following J. Chevallier recommendations.In this trial it was considered a self-administrated technique because physiotherapist only gave oral advice in order to ensure a correct performance of the technique.
OTHERSlow expiration with glottis opened in lateral posture
It was performed following Postiaux´s recommendations. In this trial the technique was considered active-assisted because the physiotherapy played a role important in their execution.
OTHERTemporary-positive expiratory pressure
The diaphragmatic breathing was required for this technique whereas patients remain seated in front of the device with a nose clip. The inspiratory /expiratory ratio was 1:2.It was taken into account as a device-administrated technique for this trial.
Sponsors
Hospital Clinic of Barcelona
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. \- Non Cystic Fibrosis bronchiectasis diagnosed by High Resolution Computed Tomographic 2. \- Mean sputum production ≥ 15 ml /24h 3. \- Clinical stability in the last 6 weeks 4. \- Not carrying out regular chest physiotherapy 5. \- Forced expiratory volume in 1 second ≥ 30% pred. ; Forced Vital Capacity ≥ 45% pred. and peak expiratory flow \>270 L/s
Exclusion criteria
1. \- Smoker or non-smoker form less than 2 years 2. \- Cystic fibrosis 3. \- Active tuberculosis or sarcoidosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Weight of sputum expectorated during each airway clearance therapy session | 40 minutes | Wet weight sputum production were recollected in one pre-weighted containers. It was measured in grams. |
| Weight of sputum expectorated 24 hours post each bronchial session | 24 hours | Wet weight sputum production were recollected in one pre-weighted containers. It was measured in grams. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Saint George Respiratory Questionnaire (SGRQ) | Change from baseline at 5 weeks | Saint George Respiratory Questionnaire (SGRQ) is a self-completed health-related quality of life questionnaire.It was validated in bronchiectasis. It was administrated at the start and at the end of trial. |
| Leicester Cough Questionnaire (LCQ) | Changes from baseline arm to 1 week | Leicester Cough Questionnaire is a self-completed quality of life measure of the impact of cough severity. It was validated in bronchiectasis. It was administrated at the start and at the end of each technique. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Lung function measured by simple spirometry: forced expiratory volume in 1 second, Forced vital capacity, Forced expiratory flow 25-75 | Change from baseline arm to 1 week | — |
| Likert test | Change from baseline arm to 1 week | It is a patient´s preferences measure. The questionnaire consists of a package of simple questions about the airway clearance techniques. |
Countries
Spain
Outcome results
None listed