Tongue Cancer
Conditions
Keywords
Anesthesia, general, Immunity, Tongue neoplasms, immune, general anesthesia
Brief summary
Surgical excision is the mainstay of treatment for tongue cancer. However, surgery-induced immunosuppression has been implicated in the development of post-operative septic complications and neoplasm metastasis. General anesthesia is considered to not only suppress surgical stress, but also affect the immune function directly，such as altering the number and activity of immune cells. It is reported that some anesthetics increase susceptibility to tumor metastasis, apparently by suppressing natural killer cell activity. Different anesthetic techniques and anesthetics used in anesthesia have shown different effects on immunity. Many of the studies were animal trials or performed in vitro; in addition, most are focused on a single drug. To date, there is little published prospective clinical research designed specifically to investigate the effects of different general anesthetic technique on immune function in patients with oral malignant tumors. The aim of this study is going to characterize the immune response of patients undergoing surgery for tongue cancer under 3 types of general anesthesia.
Interventions
PROCEDUREintravenous anesthesia
intravenous anesthesia
combined intravenous-inhalational anesthesia
PROCEDUREinhalational anesthesia
inhalational anesthesia
Sponsors
tiejun Zhang
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* All the patients were scheduled for elective surgery for tongue cancer under general anesthesia. None of the patients had a history of endocrine, immune and circulatory system diseases; *
Exclusion criteria
were also contraindications for receiving chemotherapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentages of immune cells | 3 days | 30 min before induction, 1 h, 3 h and 5 h after induction; at the end of operation and 24h, 48 h and 72 h after operation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Percentages of T lymphocytes subsets | 3 days | 30 min before induction, 1 h, 3 h and 5 h after induction; at the end of operation and 24h, 48 h and 72 h after operation |
| Percentages of Natural Killer cells | 3 days | 30 min before induction, 1 h, 3 h and 5 h after induction; at the end of operation and 24h, 48 h and 72 h after operation |
| Percentages of B lymphocytes | 3 days | 30 min before induction, 1 h, 3 h and 5 h after induction; at the end of operation and 24h, 48 h and 72 h after operation |
Countries
China
Contacts
Primary Contacttiejun zhang, M.D.
Outcome results
None listed