Coronary Atherosclerosis, Myocardial Ischemia
Conditions
Keywords
CT coronary angiography, Contrast stress echocardiography, Arterial stiffness, Quality of life, Biochemical and genetic markers
Brief summary
The aim of the study is to assess presence of myocardial ischemia by contrast stress echocardiography in patients with symptomatic non-obstructive coronary artery disease (CAD) by CT-coronary angiography, and the clinical, vascular, biochemical and genetic markers of myocardial ischemia in such patients.
Detailed description
Non-obstructive coronary artery disease (CAD) is particularly common in women and associated with reduced quality of life and increased cardiovascular morbidity and mortality. The project will recruit patients with angina pectoris and non-obstructive CAD by CT- coronary angiography for further imaging with contrast stress echocardiography for diagnosis of myocardial ischemia. Better characterization of patients with symptomatic non-obstructive CAD due to myocardial ischemia will be done by vascular assessment by tonometry, biochemical and genetic markers as well as quality of life questionnaire. This interdisciplinary project is expected to add new knowledge to the impact of multimodality cardiac imaging in improving diagnosis in patients with symptomatic non-obstructive CAD.
Interventions
None listed
Sponsors
Haukeland University Hospital
University of Bergen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \>30 years * Chest pain and or functional dyspnoea with a duration \> 6 months * Non-obstructive coronary artery disease detected by CT coronary angiography
Exclusion criteria
* Significant coronary artery stenosis or normal coronary arteries by CT coronary angiography * Unstable coronary artery disease * Significant valvular heart disease * Mechanical valve prosthesis * Significant arrhythmia * Severly reduced pulmonary function (GOLD 3-4) * Known allergy to ultrasound contrast agents * Pregnancy * Inability to sign informed consent to participate * Other severe disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence of myocardial ischemia by contrast stress echocardiography | 15 minutes, during contrast stress echocardopgraphy | Presence of delayed myocardial contrast enhancement during stress echocardiography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Extent of myocardial ischemia by contrast stress echocardiography | 15 minutes, during contrast stress echocardiography | Numbers of left ventricular segments with delayed contrast enhancement during stress echocardiography |
Countries
Norway
Outcome results
None listed