Spinal Cord Injury
Conditions
Keywords
Osteoporosis, BMD, SCI, DXA, pQCT
Brief summary
Background: After a traumatic spinal cord injury, a severe bone loss in the paralyzed extremities is observed. This leads to a osteoporosis which is connected to a high fracture risk. Aims: To compare the two measurement methods DEXA and pQCT concerning optimal diagnostics and assessment of fracture risk in subjects with spinal cord injury. Subjects: 250 women and 250 men (age≥18, any AIS-classification) with an acute or chronic spinal cord injury will be recruited for this study. For a reference group, 500 able-bodied persons will be measured analogously. Methods: Using DEXA-Osteodensitometry, bone parameters of the lumbar vertebral column, proximal femur, distal radius, distal tibia and knee area will be assessed. Additionally, geometric bone parameters of the tibia will be measured by using pQCT. All measurements will be done unilaterally. For the assessment of potential risk factors for reduced bone stiffness after spinal cord injury a questionnaire will be used.
Sponsors
Swiss Paraplegic Research, Nottwil
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Spinal Cord Injury * mobilized patients * written informed consent
Exclusion criteria
* current fracture * limited mobility * contractures of the lower limbs * decubitus ulcer * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bone parameters | just one timepoint | Measurement of the extremities with DEXA and pQCT |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fractures | just one timepoint (questionnaire) | Number of fractures since SCI |
Countries
Switzerland
Outcome results
None listed