Drug Usage
Conditions
Keywords
LMA insertion, dexmedetomidine, propofol
Brief summary
The investigators attempted to determine the optimal dose of dexmedetomidine required for the successful insertion of LMA during propofol induction without a neuromuscular blocking agent.
Detailed description
After a predetermined bolus dose of dexmedetomidine was injected over 2 min, anesthesia was induced with propofol 2.0 mg/kg. After confirming the loss of eyelash reflex and the bispectral index (BIS) score decreased below 60, the insertion of LMA was attempted.
Interventions
DRUGdexmedetomidine
The dose of dexmedetomidine was determined by modified Dixon's up-and-down method, starting from 0.5 μg/kg (0.1 μg/kg as a step size).
DRUGpropofol
Propofol 2.0 mg/kg was administrated
The insertion of laryngeal mask airway (LMA) was attempted, after confirming the loss of eyelash reflex,the bispectral index (BIS) score decreased below 60.
Sponsors
Ajou University School of Medicine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* ASA I-II patients undergoing general anesthesia for short elective surgery (\<1 hr)
Exclusion criteria
* G-E reflux * obesity (BMI\>30) * anticipated difficult airway
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| successful insertion of LMA | from baseline to 2 min after insertion of LMA (participants will be followed for the duration of anesthetic induction, an expected average of 10 min). | the response of patients to the insertion of LMA (classified as either 'movement' or 'no movement') during infusion of dexmedetomidine and propofol. |
Countries
South Korea
Outcome results
None listed