Oral Glucosestimulation After Gastric Bypass Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01851616

Enrollment

Registered

2013-05-10

Start date

2013-01-31

Completion date

2013-04-30

Last updated

2013-05-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

glucose, blood

Brief summary

The objective of this study is to examine gastric emptying and satiety hormones after oral glucose stimulation in 2 different concentrations in morbidly obese patients after Roux-en-Y-gastric-Bypass.

Detailed description

After gastric bypass many patients suffer from early and/or late dumping syndrome as a reaction to carbohydrate rich meals. Gastric emptying after bypass is accelerated and nutrition enters the intestine faster, which leads to osmotically driven fluid shifts from the blood to the lumen. Late dumping occurs 1-3 h after eating, and is caused by hyperinsulinemia and is therefore characterized by symptoms of hypoglycemia like weakness, sweating, and dizziness. Many people have both types. In most studies examining satiety hormones after oral glucose stimulation in non-operated patients, glucose loads of 50-75g are used. For a measurable GLP-1 rise a threshold of 2 kcal/min. at the intestine is needed. After gastric bypass gastric emptying is accelerated and less glucose is necessary to reach this threshold. The threshold load and tolerable load without dumping symptoms is not yet know.

Interventions

DIETARY_SUPPLEMENT25g of glucose in 200ml tap water, given orally (plus 50 mg 13C-sodium acetate)

DIETARY_SUPPLEMENT10g Glucose in 200ml tap water given orally (plus 50 mg 13C-sodium acetate)

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* 6 weeks post gastric bypass surgery, * non-diabetic patient

Exclusion criteria

* smoker, * diabetes, * gastrointestinal motility disorder, * medication influencing gastric emptying

Design outcomes

Primary

Measure	Time frame
amount of oral glucose leading to increase in satiety hormones	240 min.

Secondary

Measure	Time frame
Amount of oral glucose leading to clinical signs of dumping	240min.

Other

Measure	Time frame	Description
Gastric emptying after gastric bypass	240min	Gastric emptying is measured by means of breath test (use of 50 mg 13C-sodium acetate)

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026