Non Fluent Aphasia in Subacute Stroke
Conditions
Keywords
Aphasia, Stroke, repetitive transcranial magnetic stimulation.
Brief summary
To investigate the therapeutic effect of dual hemisphere repetitive transcranial magnetic stimulation (rTMS) on post-stroke non fluent aphasia.
Detailed description
Thirty patients with subacute post-stroke non-fluent aphasia were randomly allocated with a ratio 2:1 to receive real (n = 20) or sham (n = 10) rTMS of the affected motor cortex. Each patient received 1000 rTMS pulses (1 Hertz at 110% of resting motor threshold) over the unaffected Broca's area and 1000 pulses (20 Hertz at 100% resting motor threshold) over affected left Broca's area for 10 consecutive days. LANGUAGE section of hemispheric stroke scale, Stroke Aphasic Depression Questionnaire Hospital Version (SADQ-H) and NIH stroke scale were assessed before, post sessions, 1 and 2 months after the last session . Motor threshold was assessed before and after the end of last session.
Interventions
PROCEDURErepetitive transcranial magnetic stimulation
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* acute hemiplegia with non-fluent aphasia, single thromboembolic non-haemorrhagic infarction documented by computerized tomography (CT) in the distribution of middle cerebral artery.
Exclusion criteria
* head injury or neurological disease other than stroke, * Unstable cardiac dysrhythmia, * Fever, * Infection, * Hyperglycaemia * Prior administration of tranquilizer * Patients with no motor evoked response recorded from first dorsal interosseus (FDI) muscle of the affected hand
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hemispheric stroke scale (HSS) | Change from Baseline in HSS at 2 months | Language assessment using hemispheric stroke scale (HSS) |
Secondary
| Measure | Time frame |
|---|---|
| NIH Stroke Scale (NIHSS) | Change from Baseline in NIHSS at 2 months |
Other
| Measure | Time frame | Description |
|---|---|---|
| Stroke Aphasic Depression Questionnaire Hospital Version (SADQ-H) | Change from Baseline in SADQ-H at 2 months | (Asking about presence of depressive symptoms within last week of stroke to be present all the days or frequent from 4-6 days, or infrequent from 1-4 days, or not at all). |
Outcome results
None listed