Assessment of Coronary Artery Disease in Stroke Patients

Prevalence and Characteristics of Coronary Atherosclerosis in Stroke Patients Using Coronary CT Angiography

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01850693

Acronym

ACADIS

Enrollment

1657

Registered

2013-05-09

Start date

2006-07-31

Completion date

2015-06-30

Last updated

2015-11-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

coronary artery disease, stroke, coronary CT angiography

Brief summary

This study is to evaluate the prevalence, plaque characteristics (plaque types, stenosis degree, remodeling) and predictors of coronary atherosclerosis in stroke patients with coronary CT angiography.

Detailed description

Stroke and coronary artery disease (CAD) share common risk factors and pathological mechanisms. CAD is an important cause of death in patients with stroke. Currently, coronary CT angiography (CCTA) is very useful non-invasive tool for detection of CAD and plaque analysis. Therefore, the investigators aimed to evaluate the prevalence, plaque characteristics (plaque types, stenosis degree, remodeling) and predictors of CAD in stroke patients through follow-up (more than 5 years) using CCTA.

Interventions

None listed

Study design

Observational model

COHORT

Eligibility

Sex/Gender

ALL

Age

30 Years to No maximum

Healthy volunteers

Inclusion criteria

* Acute stroke patients who diagnosed by clinical and brain MR imaging * Who performed coronary CT angiography within 3 months after acute stroke

Exclusion criteria

* intracranial hemorrhage including intracerebral, subdural or subarachnoid hemorrhage * brain tumor * Previous myocardial infarction * Previously performed percutaneous coronary intervention (PCI), coronary artery bypass graft (CABG) or other cardiac surgery * Insufficient medical record * Poor image quality of CCTA scan

Design outcomes

Primary

Measure	Time frame	Description
MACE (Major Adverse Cardiac Event)	Participants will be followed until June. 2015, an expeded average of 5 years	MACE was included as follows: 1) all-cause mortality, 2) myocardial infarction, 3) unstable angina requiring hospitalization

Secondary

Measure	Time frame	Description
Any cardiac events	Participants will be followed until June. 2015, an expeded average of 5 years	1\) late revascularization: who underwent revascularization therapy mroe than 90days after CCTA and referral due ot new symptoms or an abnormal function test, 2) heart failure required hospitalization.

Other

Measure	Time frame	Description
Repeated stroke	Participants will be followed until June. 2015, an expeded average of 5 years	newly developed stroke after CCTA scan

Countries

South Korea

Outcome results