Obesity
Conditions
Keywords
Obesity, MC4R, Blood pressure, Blood glucose
Brief summary
Mutations in the melanocortin 4 receptor (MC4R) are the most common form of monogenic obesity, and can explain 2-6% of severe obesity. Studies have shown that mutations in MC4R are associated with increased fat mass, height-for-age, appetite and insulin resistance among children. In adults, mutations in MC4R are less penetrant for these phenotypes but it has been observed that individuals with MC4R mutations have a smaller than expected blood pressure for their degree of obesity. The purpose of this study is to explore the association between functional MC4R mutations and obesity, insulin resistance and blood pressure.
Interventions
OTHERNo intervention
Sponsors
Rhythm Pharmaceuticals, Inc.
University of Copenhagen
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-70 years * Men and women * BMI \> 30 kg/m\^2
Exclusion criteria
* Uncontrolled type 2 diabetes * Bariatric surgery * Use of anti-obesity medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure | Baseline | Systolic and diastolic blood pressure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Obesity | Baseline | Obesity measured as BMI |
| Blood glucose | Baseline | Blood glucose measured at baseline |
| MC4R mutations | Baseline | MC4R mutations detected by sequencing of the coding region of the MC4R gene |
Countries
Denmark
Outcome results
None listed