Breast Cancer
Conditions
Brief summary
The purpose of this research study is to demonstrate that Deep Inspiration Breath Hold (DIBH), the technique used at the University of North Carolina (UNC) for left-side breast cancer radiation therapy, can reduce side effects to the heart.
Detailed description
The primary objective of this study is to estimate the rate of radiation-associated regional myocardial perfusion defects in patients 6 months after breast/chestwall radiation with DIBH for left-sided breast cancer. Cardiac perfusion will be assessed using SPECT cardiac perfusion scans pre- and 6 months post-radiation.
Interventions
OTHERCardiac SPECT perfusion scan
A SPECT cardiac perfusion scan provides a three-dimensional map of blood flow to the heart tissue. The scan will be taken at rest only.
Sponsors
UNC Lineberger Comprehensive Cancer Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* signed an Institutional Review Board (IRB)-approved informed consent document for protocol * age \>= 18 years * histologically confirmed left-sided breast cancer scheduled to undergo curative intent radiation treatment post lumpectomy or mastectomy * stage 0-III left-sided breast cancer (including DCIS) * SPECT score of 0 at baseline * radiation oncologist agrees target volume coverage will not be compromised via use of the DIBH technique along with conformal field shaping
Exclusion criteria
* active cardiac disease, defined as a history of angina, arrhythmias, myocardial infarction, congestive heart failure, or any other cardiac condition, which in the opinion of the treating physician would make this protocol unreasonably hazardous for the patient * symptomatic pulmonary disease currently requiring regular medication including but not restricted to bronchodilators * concurrent chemotherapy * prior receipt of mediastinal radiation therapy * pregnant or lactating women * inability to understand and follow breathing instructions for the DIBH procedure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in cardiac perfusion | 6-months post radiation | Cardiac perfusion will be assessed using SPECT cardiac perfusion scans pre- and 6 months post-radiation. Any post-radiation summed-rest score (SRS) \> 0 will be counted as a perfusion defect in the calculation of the perfusion defect rate. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Wall-motion abnormalities | 6-months post-treatment | The incidence of wall-motion abnormalities will be assessed using SPECT in the same 12 segment scoring system used to quantify perfusion. Wall-motion abnormalities will be recorded as present or absent in each cardiac segment. When present, wall-motion abnormalities wil be classified as gypokinetic, akinetic, or dyskinetic. The extent of wall involvement (small or large portion) will be described as mild or severe. |
Countries
United States
Outcome results
None listed