Influence of Neuromuscular Block on Mask Ventilation

Influence of a Neuromuscular Block on Face Mask Ventilation Conditions During Induction of Anaesthesia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01849211

Enrollment

120

Registered

2013-05-08

Start date

2013-04-30

Completion date

2018-03-31

Last updated

2020-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effect of a Neuromuscular Block on Ventilation

Keywords

ventilation, face mask, NMBA

Brief summary

Difficult mask ventilation might lead to a life-threatening situation, if endotracheal intubation is also impossible and neuromuscular blocking agents (NMBA) inhibit spontaneous ventilation. However, controversies exist if NMBA improve or impede face mask ventilation. Therefore, the effect of NMBAs on mask ventilation is assessed in patients with predictors for difficult face mask ventilation.

Interventions

DRUGrocuronium

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with risk factors for difficult face mask ventilation * Patients scheduled for general anaesthesia with endotracheal intubation

Exclusion criteria

* Increased Risk for pulmonary aspiration * scheduled for awake fiberoptic intubation * pregnancy

Design outcomes

Primary

Measure	Time frame
minute volume	15 min (from Induction of anaesthesia until onset of NMBA )

Secondary

Measure	Time frame
incidence of difficult mask ventilation - tidal volume < 150 ml	15 min

Other

Measure	Time frame	Description
airway pressure	15 min	measurement of peak airway pressure

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026