Metabolic Syndrome
Conditions
Keywords
5-10 gram astragalus per day
Brief summary
Metabolic syndrome have the damages on tissues and organs in heart、kindey and vessels. In this study, prospective randomized, controlled, parallel designed ,different doses of Astragalus Mongolia, Gansu Longxi produce treat on the MS patients, and then use real-time quantitative PCR and Western Blotting to detect the index of oxidative stress 、angiotensin-converting enzyme 2 mRNA expression and proteins.
Interventions
DRUGlow dose Astragalus
DRUGhigh dose astagalus
Sponsors
LanZhou University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. age 18 years or older, meet the diagnostic criteria of MS 2. non-allergic with the astragalus 3. agree to conduct clinical trials and those who signed the informed consent
Exclusion criteria
1. patients with resistant hypertension 2. renal disease requiring dialysis 3. heart failure NYHA ⅢorⅣ; 4. complications of diabetes 5. arteritis 6. cancer 7. thyroid disease 8. unstable coronary heart disease 9. peripheral vascular disease 10. acute cerebral vascular disease11.pregnancy、 planned pregnancy 11. patients with anti-oxidants 12. acute infection 13. other organic dysfunction, such as the liver, respiratory system, blood system, and other rheumatic diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| index of cardiac function | one year | ues echocardiography to measure the cardiac function |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure | one year |
Other
| Measure | Time frame |
|---|---|
| kidney function | one year |
| Central Blood Pressure | one year |
| Ankle Brachial Index | one year |
Countries
China
Outcome results
None listed