Insulin Sensitivity
Conditions
Keywords
whole body insulin sensitivity, insulin action in the brain
Brief summary
The researchers will investigate if brain insulin action influences peripheral insulin sensitivity in healthy humans.
Interventions
DRUGhuman insulin as nasal spray
DRUGPlacebo
Sponsors
University Hospital Tuebingen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI \< 28 kg/m2 * normal HbA1c * healthy volunteers
Exclusion criteria
* Heparin induced thrombocytopenia (HIT) * metal implants * cardial diseases * anemia * patients taking any kind of drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Insulin sensitivity as measured by clamp | 45 minutes to 120 minutes post nasal spray | We will measure insulin sensitivity by hyperinsulinemic euglycemic clamp before and after nasal spray application. We will compare the post-spray insulin sensitivity between the two condition (insulin nasal spray vs placebo nasal spray). Furthermore, we will compare insulin sensitivity before and after nasal insulin application. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Autonomous nervous system activity | 45 to 120 minutes post spray | Activity of the autonomous nervous system will be estimated by heart rate variability in ECG. We will compare the post-spray autonomous nervous system activity between the two condition (insulin nasal spray vs placebo nasal spray). Furthermore, we will compare autonomous nervous system activity before and after nasal insulin application. |
Countries
Germany
Outcome results
None listed