Asthenozoospermia
Conditions
Brief summary
Since docosahexaenoic acid (DHA) level in sperm membrane has been shown to be decreased in asthenozoospermic men, the investigators hypothesized that DHA supplementation may improve it. Furthermore, the investigators added vitamin E to it to protect its unsaturated bonds which are susceptible to oxidation and production of free oxygen radicals.
Interventions
DIETARY_SUPPLEMENTvitamin E
DIETARY_SUPPLEMENTDHA
OTHERplacebo
Sponsors
National Nutrition and Food Technology Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
20 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Willing to participate in the study and filling out the informed consent form * should be infertile (no conception after 12 months intercourse without any contraception) * age 20-45 y.o, idiopathic asthenospermia according to WHO criteria * normal hormonal profile
Exclusion criteria
* any infection in genitourinary (GU) tract * any anatomical abnormality in GU tract * any chronic disease during last 3 months * any surgery in GU tract * consumption of omega-3 fatty acids and/or vitamin E supplements during last 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sperm motility | 12 weeks | spermatogram |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| sperm count | 12 weeks | spermatogram |
| seminal oxidative stress | 12 weeks | ELISA |
Outcome results
None listed