Sodium Intake in Multiple Sclerosis

Effect of Sodium Intake in Multiple Sclerosis Disease Activity

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01846234

Acronym

SALT

Enrollment

132

Registered

2013-05-03

Start date

2010-11-30

Completion date

2013-07-31

Last updated

2013-10-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis

Keywords

Multiple Sclerosis, Salt

Brief summary

Recently, it has been shown that salt (ClNa, sodium chloride) can modulate the differentiation of human and mouse TH17 cells. Indeed, mice feed with high sodium diet were described to develop more aggressive course of EAE (Experimental Autoimmune Encephalitis). However, the role of sodium intake in MS has not been investigated. In this study we investigate the effect of sodium intake in Multiple Sclerosis (MS) clinical and radiological activity.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Subject is between 18 and 50 years old * Subject has diagnosis of relapsing-remitting MS according to McDonald criteria (2010)

Exclusion criteria

* Patient who had hyponatremia in the last 90 days

Design outcomes

Primary

Measure	Time frame	Description
Exacerbation rate	2 years	Number of disease relapses during follow up time according to salt consumption

Secondary

Measure	Time frame	Description
Radiological activity	One year	Number of new lesions in MRI

Countries

Argentina

Outcome results