Healthy Controls, Multiple Sclerosis
Conditions
Keywords
high intensity interval training, combined training, insulin resistance, muscle contractile properties
Brief summary
The purpose of this study is to investigate the effects of a combined training programme and a high intensity interval training programme on insulin resistance, muscle strength/ muscle contractile properties, aerobic capacity and body composition in MS patients. It is assumed that the the above mentioned clinical parameters will improve due to physical exercise.
Interventions
BEHAVIORALTraining
Sponsors
Bert Op't Eijnde
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Diagnosed MS according to the McDonald criteria * Expanded Disability Status Scale (EDSS) between 0.5 and 6 * Be able to train 5 times in 2 weeks at the University
Exclusion criteria
* Comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases (like diabetes type 2) * Having had an relapse in a period of 3 months prior to the start of the intervention period * Having an relapse during the intervention period * Pregnancy and other contra indications for physical activity * Mental disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| insulin sensitivity (insulin profile) | change from baseline to 12 weeks | glucose and insulin concentration measurements in blood |
| muscle contractile properties | from baseline to 12 weeks | measurements of cross sectional area and fiber distribution in muscle fibers of the m. vastus lateralis + measurements of enzymatic reactions, ATP, glycogen, ... |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cytokine profile | change from baseline to 12 weeks | measurements of blood cytokine levels |
| muscle strength of knee extensor/flexor | change from baseline to 12 weeks | by means of an isokinetic dynamometer the muscle strength and endurance will be measured |
| body composition | Change from baseline to 12 weeks | Weight, body fat% and lean tissue% will be assessed by means of a DEXA scan |
| Self-reported measures | Change from baseline to 12 weeks | The self-reported measures contains some questionnaires |
| aerobic capacity | change from baseline to 12 weeks | by means of a submaximal endurance test (ergometer) |
Countries
Belgium
Outcome results
None listed