Obesity
Conditions
Keywords
Obesity, Bariatric surgery, Cefazolin, antimicrobial prophylaxis, administration and dosage
Brief summary
Eighteen patients were given a dose of 2g Cefazolin in anesthetic induction, supplemented with 1g delivered through continuous infusion during surgery. Adipose samples, obtained at the beginning and end of surgery, were analyzed using high performance liquid chromatography. Some published studies suggest that the dose of 2g does not supply the minimum inhibitory concentration for principal causal agents of surgical site infection. To determine the concentration of Cefazolin in adipose tissue of patients undergoing bariatric surgery and to evaluate the relationship between concentrations obtained and body mass index (BMI).
Interventions
DRUGCefazolin used in antimicrobial prophylaxis
Cefazolin administered a first dose of 2g in anesthetic induction, followed by continuous dosage of 1g diluted in 250mL of saline solution for two hours. Two samples of subcutaneous tissue were collected for analysis: the first soon after the incision, and a second before skin synthesis. The samples were processed by HPLC.
Sponsors
Universidade Federal de Pernambuco
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* body mass index greater than 35 and less than 50kg/m2
Exclusion criteria
* Hypotension during surgery with use of vasoactive drugs * renal disfunction (creatinine \>1.5 mg/dL)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| dosage of Cefazolin in adipose tissue during bariatric surgery | eight months |
Countries
Brazil
Outcome results
None listed