Other Nonspecific Abnormal Serum Enzyme Levels
Conditions
Brief summary
To compare the effect of lanthanum carbonate with calcium carbonate on serum FGF23 levels in hemodialysis patients.
Detailed description
The investigators enrolled patients on maintenance hemodialysis and randomized them to two groups. One group will receive lanthanum carbonate and another group will receive calcium carbonate. The investigators will compare serum FGF23 levels between two groups after they receive above medication for 6 months.
Interventions
DRUGLanthanum carbonate
the effect on serum FGF23
DRUGCalcium Carbonate
Calcium carbonate 500mg\ 1000 mg tid for 6 months
Sponsors
Camillians Saint Mary's Hospital Luodong
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 18 years old * Chronic renal failure on maintenance hemodialysis 3 times a week for at least 3 months Serum calcium:8-10.5 mg/dL * Serum phosphate:3.5-6 mg/dL(before washout period) * Serum phosphate ≧6 mg/dL after washout period * Serum i-PTH: 150-600 pg/mL
Exclusion criteria
* Diabetes mellitus * Post parathyroidectomy * Life expectancy\< 6 months * Liver disease(hepatitis B,C or liver dysfunction) * Severe gastrointestinal disorders or other severe comorbidity * Poor compliance * Intolerance to lanthanum or calcium carbonate * Active infection * Malnutrition(serum albumin\<3 g/dL or clinical assessment) * Kt/V\< 1.2 (inadequate dialysis) * Serum phosphate\>7.5 mg/dL after washout period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum level of fibroblast growth factor | 6 months |
Countries
Taiwan
Contacts
Primary ContactYu-Ming Chang, MD
Outcome results
None listed