The Effects of Dietary Fiber in CKD: A Systematic Review and Meta-analysis

The Effects of Dietary Fiber on Uremic Retention Solutes in CKD: A Systematic Review and Meta-analysis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01844882

Enrollment

Registered

2013-05-03

Start date

2012-01-31

Completion date

2013-08-31

Last updated

2014-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease

Keywords

The effects, dietary, fiber, kidney function, CKD patients

Brief summary

Chronic kidney disease (CKD) is a debilitating condition in which there is a gradual decline of renal function associated with increased overall mortality. Most dietary guidelines for CKD focus on limiting protein intake (nitrogen) and high phosphorus-containing foods. However, increasing dietary fiber has been proposed to increase fecal nitrogen excretion which may ameliorate the progress of CKD. We therefore plan to conduct a systematic review and meta-analysis on clinical trials to assess the effect of fiber on urea and creatinine as classical markers of a state of uremia in individuals with CKD. We hypothesize that increasing fiber intakes will improve urea and creatinine levels in individuals with CKD.

Interventions

None listed

Study design

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Dietary trials in humans * Randomized treatment allocation * Suitable control (low fiber) * viable endpoint data

Exclusion criteria

* Non-human studies * Nonrandomized treatment allocation * Lack of a suitable control (high protein) * no viable endpoint data

Design outcomes

Primary

Measure	Time frame
Creatinine	1.5 years
urea	1.5 years

Secondary

Measure	Time frame
Phosphorus	1.5 years

Outcome results