Digestive System Disease
Conditions
Keywords
Digestive System Diseases Disease
Brief summary
The purpose of the study is to treat patients with on-going slow stomach emptying(gastroesophageal reflux disease), who have failed to respond to standard therapy
Detailed description
This is a study on the effectiveness of domperidone, which increases movement through the digestive system for relief of symptoms, in patients who have delayed gastric solid-phase emptying
Interventions
OTHERDomperidone
Domperidone dosage may be increased depending on how well the patient responds. However before increasing the dosage, patients will have follow-up EKG to evaluate any possible side effects including irregular heartbeats.
Sponsors
Mt. Sinai Medical Center, Miami
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
12 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Persistent esophagitis * Heartburn * Nausea * Vomiting * Severe dyspepsia * Severe chronic constipation
Exclusion criteria
* History of, or current arrhythmias including ventricular tachycardia, - Ventricular fibrillation and Torsade des Pointes.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical Applications of Domperidone in Patients with Refractory Gastroesophageal Reflux Disease (GERD)or Delayed Gastric Solid-Phase Emptying | 5 years | GERD or Delayed Gastric Emptying |
Countries
United States
Outcome results
None listed