Primary Uterine Infertility
Conditions
Keywords
uterus, transplantation, infertility
Brief summary
Uterus transplantation, as a possible future treatment for uterine factor infertility, has been developed in animal species during the last decade. The study protocol includes transplantation of the uterus from a live donor (mother, relative, friend) into women with absolute uterine factor infertility (lack of uterus from birth or due to life saving hysterectomy).The recipient will be treated by standard immunosuppression and transfer of embryos (acquired by IVF before surgery) will be attempted when at least 12 months have passed from transplantation. Approval for a case series including up to 10 patients has been acquired.
Detailed description
The study is ongoing, with inclusion of 9 patients.
Interventions
PROCEDUREuterine transplantation
Transplantation of the uterus from live donor and IVF treatment.
Sponsors
The Swedish Research Council
Sahlgrenska University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
* less than 39 years * good general health
Exclusion criteria
* poor ovarian resaerve or older than 39 years * systemic or psychiatric disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| surviving transplants (12 months) | up to 3 years after transplantation |
Secondary
| Measure | Time frame |
|---|---|
| pregnancy rate | up to 3 years after transplantation |
Other
| Measure | Time frame |
|---|---|
| live birth rate | up to 4 years after transplantation |
Countries
Sweden
Outcome results
None listed