Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01843101

Enrollment

Registered

2013-04-30

Start date

2014-03-14

Completion date

2016-10-24

Last updated

2021-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Corneal Neovascularisation, Keratoconus

Keywords

Optical Coherence Tomography, Cornea, Imaging

Brief summary

The aim of the present study is to develop a protocol for optimal corneal 3-dimensional imaging based on measurements in healthy volunteers. For this purpose, a customized ultra-high resolution Spectral Domain OCT will be used. To validate whether the protocol can also be applied in patients with corneal pathologies, for whom it is intended to be used, measurements in these patients will be performed. We propose to obtain images from patients with keratoconus, since this is one of the most frequent causes for corneal transplantations in Europe and from patients with corneal neovascularization which is a major cause of vision loss in several ophthalmic diseases. Based on the obtained measurement protocol, further studies investigating the pathophysiology or treatment success of several corneal pathologies can be planned.

Interventions

DEVICEOptical Coherence Tomography

Imaging of the cornea using ultrahigh resolution Spectral Domain OCT

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Healthy volunteers: * Men and women aged over 18 years * Normal findings in the slit lamp examination, no corneal pathologies Patients with keratoconus: * Men and women aged over 18 years * Presence of keratoconus * No ophthalmic surgery in the 3 months preceding the study Patients with corneal neovascularization: * Men and women aged over 18 years * Presence of corneal neovascularization * No ophthalmic surgery in the 3 months preceding the study

Exclusion criteria

* Participation in a clinical trial in the previous 3 weeks * Presence of any abnormalities preventing reliable measurements as judged by the investigator * Pregnancy, planned pregnancy or lactating

Design outcomes

Primary

Measure	Time frame	Description
Corneal Imaging	1 day	Development of a measurement protocol for 3 dimensional imaging of the human cornea

Secondary

Measure	Time frame	Description
Imaging of corneal pathologies	1 day	Application of the protocol in patients with corneal pathologies

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026