The Initial Effect of Training on Mitochondrial Function in Patients With Intermittent Claudication

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01842412

Enrollment

Registered

2013-04-29

Start date

2013-04-30

Completion date

2014-05-31

Last updated

2016-10-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intermittent Claudication

Keywords

Mitochondria, Muscle, Exercise

Brief summary

The hypothesis of this study is that one bout of leg exercise gives acute qualitative changes in mitochondrial function in claudication. Final purpose is to determine the optimal exercise frequency in treatment of claudication.

Interventions

BEHAVIORALexercise

one bout of exercise training

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* A history of any type of uni- or bilateral exertion leg pain. * A maximal claudication distance that is less than 300 meter * Diagnosed with intermittent claudication secondary to vascular insufficiency * An ankle-brachial index between 0.4 and 0.9. * Lives in Trondheim

Exclusion criteria

* Diagnosed with critical limb ischemia * ankle-brachial index \> 0.90 or \< 0.4 * Limited exercise tolerance * Warfarin or heparin usage * Diabetes mellitus * Underwent a vascular intervention in the last 3 months * Active cancer, renal- or liver disease.

Design outcomes

Primary

Measure	Time frame	Description
Mitochondrial function	One day	respirometry

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 28, 2026