To Compare the Strategies of Universal Antibiotic Prophylaxis Versus Screen-and-treat in Reducing Infective Complications and Re-infection in Women Who Undergo Termination of Pregnancy

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01842100

Enrollment

2193

Registered

2013-04-29

Start date

1999-09-30

Completion date

2006-02-28

Last updated

2013-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Induced Abortion, Postaboral Pelvic Inflammatory Disease, Sexually Transmitted Infections

Keywords

Induced abortion, Postaboral pelvic inflammatory disease, Sexually transmitted infections, Universal antibiotic prophylaxis, Screen-and-treat approach

Brief summary

Screen-and-treat approach reduces postabortal pelvic inflammatory disease after induced abortion, and at the same time alters women's sexual behavior and prevents further re-infection by sexually transmitted infections when compared to the universal antibiotic prophylaxis strategy.

Detailed description

While universal antibiotic prophylaxis during induced abortion has been proven to reduce postabortal pelvic inflammatory diseases, screen-and-treat approach has the potential benefit of altering women's sexual behavior and preventing further re-infection by sexually transmitted infections. We conducted a randomized controlled trial to compare the effect of the two approaches in preventing postabortal pelvic inflammatory disease and the women's sexual behavior.

Interventions

DRUGUniversal antibiotic prophylaxis

100 mg twice daily for 7 days starting on the day of induced abortion

OTHERScreen-and-treat

Specific antibiotic treatment was only given if the women was found to have sexually transmitted infection(s) on screening.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Inclusion criteria

* women requesting for induced abortion in the gynecology clinic

Exclusion criteria

* nil

Design outcomes

Primary

Measure	Time frame
Rate of postabortal inflammatory disease 6 weeks after induced abortion.	6 weeks after induced abortion.

Secondary

Measure	Time frame
Rate of re-infection by sexually transmitted infections 24 weeks after induced abortion.	24 weeks after induced abortion.
Proportion of women having abstinence from sexual intercourse or using condom at 6 weeks, 24 weeks and 1 year after induced abortion.	6 weeks, 24 weeks and 1 year after induced abortion

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026