Dementia
Conditions
Keywords
Glycemic load, memory, mood
Brief summary
A lower rather than a higher glycemic load (GL) meal has been shown to benefit cognition and mood, however, the data in older adults and those most prone to cognitive dysfunction, is limited and conflicting. One explanation is that the GL of a meal may interact with a person's pre-existing glucose tolerance (GT). As older adults have a higher incidence of glucose tolerance and are more likely to experience memory problems the present study considers the interaction between the GL of meal in those with better or poorer GT. The population studied will not have a history of diabetes or dementia. A battery of cognitive tests will be administered after meals sweetened with one of three sugars known to vary in the rate that they release glucose into the blood stream.
Detailed description
On day one subjects will take an oral glucose tolerance test and will then be divided into four groups depending on their glucose tolerance (how long values remain raised) and the tendency for values to subsequently fall to low values. On a second occasion 155 healthy older adults, aged 45-80 years, will be randomly assigned to receive either a glucose, sucrose or isomaltulose based meal. All meals are matched on macronutrient composition and differ only in glycemic load. Cognitive performance and mood will be assessed 30, 105 and 180 minutes after breakfast. Measures of memory, attention, reaction times and mood will be taken. The response to the three meals will be contrasted in those with different glucose profiles on day one
Interventions
DIETARY_SUPPLEMENTIsomaltulose
Isomaltulose sweetened meal will be given to each of four groups who differ in their glucose tolerance
DIETARY_SUPPLEMENTSucrose
Sucrose sweetened meal will be given to each of four groups who differ in their glucose tolerance
DIETARY_SUPPLEMENTGlucose
Glucose sweetened meal will be given to each of four groups who differ in their glucose tolerance
Sponsors
Swansea University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
45 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy adults of 45 to 80 years
Exclusion criteria
* Type 1 or type 2 diabetes * Dementia * Liver disease * Gastro-intestinal problems
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in episodic memory | 30, 105, 180 minutes | Episodic memory assessed by asking subjects to recall a list of words |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in mood | 30, 105, 180 minutes | Visual analogues scales used to report mood at six points during study |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change in reaction Times | 30, 105, 180 minutes | 1,2,4 and 8 lamps will be monitored and the time taken to extinguish will be measured |
| Change in vigilance | 30, 105 and 180 minutes | Digits will be generated at rate of 100 per minute. Subjects indicate when they see either three odd or three even in a row |
Countries
United Kingdom
Outcome results
None listed