Healthy
Conditions
Keywords
Bitter Taste, Pediatric Medications
Brief summary
This proposal describes a pilot study aimed at determining whether genetic variations in taste receptors determine differential taste tolerability of pediatric medications.
Detailed description
This is a cross-sectional call-back study of taste perception and the relationship between taste perception and taste receptor genotype.
Interventions
None listed
Sponsors
Children's Hospital of Philadelphia
University of Pennsylvania
National Institute on Deafness and Other Communication Disorders (NIDCD)
Monell Chemical Senses Center
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Adult females who were previously enrolled in Efficacy of Bitter Blockers on Taste Acceptance in Pediatric Populations Study (Protocol #809789)
Exclusion criteria
* Women who are pregnant * Women on drugs with potential serious adverse effects that are mediated through cytochrome P450.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Psychophysical data for taste solutions | 1-2 hours | Primary outcome variables are intensity ratings of pediatric medications as well as a variety of generally recognized as safe bitter and non-bitter compounds. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Maternal practices and perceptions of medication use | 1-2 hours | Secondary outcome variables include questions related to maternal practices and perceptions of medication use and compliance of their children. |
Countries
United States
Outcome results
None listed