Healthy Subjects
Conditions
Keywords
young healthy subjects, brain stimulation, tSOS, tDCS, sleep, daytime sleep, nap, memory, memory consolidation
Brief summary
The beneficial effect of daytime sleep on memory consolidation has been shown in young, healthy subjects. Especially, periods rich in slow-wave sleep (SWS) have shown a memory enhancing effect on hippocampus-dependent declarative memory. Slow oscillatory activity typically occuring during SWS has been implicated in the consolidation effect. In this study we investigate if the consolidation effect can be amplified by the application of a weak transcranial oscillatory electric current within the frequency range of SWS in humans (0,7-0,8 Hz) during daytime SWS.
Interventions
DEVICEbrain stimulation
oscillating direct current brain stimulation
DEVICEno stimulation
sham Stimulation
Sponsors
Charite University, Berlin, Germany
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy Subjects * unobtrusive, neuropsychological screening * age: 18-35 years * right handed
Exclusion criteria
* untreated severe internal or psychiatric diseases * epilepsy * other severe neurological diseases eg., previous major stroke, brain tumour * contraindications to MRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS | 4 weeks | Retention between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Amount of Slow wave Sleep | 4 weeks | 1\. Amount of slow wave sleep assessed by standard polysomnographic criteria in 0,75 Hz vs SHAM stimulation during SWS. |
| 2. sleep spindles | 4 weeks | 2\. Spindle activity during sleep indicated via several spindle parameters like number, duration, frequency of spindles; compared between 0,75 Hz and SHAM stimulation during SWS. |
| 3. EEG-correlates | 4 weeks | 3\. Neuronal correlates (EEG-power in slow oscillation frequency bands induced by 0,75 Hz vs SHAM stimulation during SWS; EEG-correlates of encoding and retrieval of a declarative memory task). |
| 4. further memory systems | 4 weeks | 4\. Performance in further memory systems (procedural), compared between 0,75 Hz and SHAM stimulation during SWS. |
Countries
Germany
Outcome results
None listed