Spinal Injury
Conditions
Keywords
S-100B, NSE
Brief summary
The hypothesis of this study is to find evidence if there is an influence of spine surgery on the serum levels of two proteins secreted from neuronal cells.
Detailed description
The question, if there is an effect on the cerebrospinal system during spine surgery, which can be traced by monitoring serum levels of neuromarkers is not yet answered. This study has its background from other studies on patients with traumatic brain injury (TBI), in whom elevated serum levels of the two neuromarkers S-100B and NSE are associated with injury severity, neuronal damage, brain, tissue damage, and outcome. Patients undergoing spine surgery with or without pre-existing traumatic neurologic symptoms are planned to be the study cohort. Pre- and postoperatively the serum levels of S-100B and NSE are obtained and are statistically compared with patients undergoing other types of bone-related surgery.
Interventions
None listed
Sponsors
Medical University of Vienna
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* spine fracture
Exclusion criteria
* additional traumatic brain injury * fractures of the long bones * polytrauma * severely injured patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| S-100B levels | 4 hours | average timeframe between blood withdrawal (twice, pre-and post-operatively) |
Countries
Austria
Outcome results
None listed