Acute Kidney Injury
Conditions
Keywords
sodium bicarbonate, acute kidney injury, OPCAB
Brief summary
In this single-site, randomized, controlled and double-blind clinical trial, the investigators evaluate the effect of sodium bicarbonate on prevention of acute kidney injury in high risk patients undergoing off pump coronary bypass surgery.
Interventions
DRUGsodium bicarbonate
BIVON group were received 0.5 mmol/kg of sodium bicarbonate for 1hours after induction of anesthesia and following 0.15 mmol/kg of sodium bicarbonate during the operation.
DRUGnormal saline
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients older than 20 years * scheduled for elective coronary artery bypass grafting. * preoperative estimated glomerular filtration rate (eGFR) : 30 \ 89 % * LVEF \< 35% * NYHA class III or IV * age \> 70 * DM * reoperation
Exclusion criteria
* acute renal impairment * patients who receive dialysis * patients who receive steroid ( \> 10mg/day prednisolon or equivalent) * hemo-alkalosis * hypernatremia * pulmonary edema * Hemoglobin \< 10 mg/dL
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| compare the incidence of acute kidney injury | Change of Indexes of renal function including SCr, cystatin C, creatinine clearance from 24 hrs before operation to postoperative day (POD) 5. | The diagnostic criteria for AKI is followed by AKIN criteria (absolutely increase in the SCr concentration ≥ 0.3 mg/dL from baseline, ≥ 50% increase in the SCr concentration within 48 hours after operation). |
Countries
South Korea
Outcome results
None listed