Fasting, Metabolism, Nutrition Support
Conditions
Brief summary
The purpose of this study is to investigate metabolic effects of 3 different nutritional compounds. Fasting (36 hours) creates a catabolic state that is comparable with the catabolic state seen in acute illness. This study is a randomized, placebo cross-over study investigating 8 healthy men on 4 separated days (at least 3 weeks between trials). * High leucine content drink * Low leucine content drink * Low leucine content drink + HMB * Carbohydrate (isocaloric) The investigators hypothesize that these nutritional supplements may counteract catabolic processes in different ways and degrees.
Interventions
DIETARY_SUPPLEMENTlow leucine content drink
DIETARY_SUPPLEMENThigh leucine content drink
DIETARY_SUPPLEMENTlow leucine + HMB drink
DIETARY_SUPPLEMENTControl/carbohydrate
BEHAVIORAL36 hour fasting
Sponsors
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* male gender * 20\<BMI\<30 * Age \> 20 years old * Written consent before starting the study
Exclusion criteria
* Allergy for soya products ore egg * Diabetes * Epilepsy * Infection * Immune defects * Heart disease * Dysregulated hypertension * Participating in other trials using radioactive tracers or x-rays the last year.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Protein metabolism after 36 hours fasting receiving different nutritional supplements. | 3 control period followed by 4 hours of nutritional drink intake | Protein metabolism is measured with amino acid tracer techniques comparing marked amino acids from blood samples. Muscle and fat biopsies are obtained for signaling analysis. Indirect calorimetry measurements are used to compare metabolism in the control period and during the intervention. |
Countries
Denmark
Outcome results
None listed