Obesity, Morbid
Conditions
Keywords
bariatric surgery, alcohol drinking, alcoholism, ethanol, metabolism
Brief summary
The first-pass metabolism (FPM) is a barrier to the toxicity of ethanol. Changes to the size and function of the stomach may alter FPM. Bariatric surgery, like the gastric bypass procedure, involves significant changes to the size and function of the stomach and leads to more rapid gastric emptying. Consequences will be faster absorption and higher peak concentration of ethanol after surgery than before. There are growing concerns that surgery for obesity in this way may cause alcohol abuse. In this study the investigators compare changes in FPM of ethanol following two different bariatric surgical procedures.
Interventions
PROCEDUREGastric bypass
Surgical procedure in which the stomach is transected high on the body. The resulting small proximal gastric pouch is joined to any parts of the small intestine by an end-to-side surgical anastomosis.
PROCEDUREgastric sleeve
Sleeve gastrectomy, a surgical procedure in which the stomach is reduced to about 25% of its original size, by surgical removal of a large portion of the stomach, following the major curve. The open edges are then attached together (often with surgical staples) to form a sleeve or tube with a banana shape.
Sponsors
St. Olavs Hospital
Norwegian University of Science and Technology
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* volunteers from Central Norway * morbid obese BMI \> 40 kg/m2) * morbid obese BMI \> 35 kg/m2 given a obesity related disease that qualifies for bariatric surgery
Exclusion criteria
* previous or current alcohol abuse * risk for alcohol harm as assessed by AUDIT * alcohol abstinence * liver disease except fatty liver, which occurs in more than 50% of those who seek bariatric surgery * previous colon resection * not/insufficiently able to informed consent * drugs that interact with alcohol dehydrogenase * drugs that slow down emptying of the stomach * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in bioavailability of ethanol | from baseline to 3 months, 1 year, and 3 years | bioavailability tests: Plasma concentration of ethanol. Calculation: * Area under curve (AUC) * Maximum concentration(Cmax) * Time up to maximum concentration (tmax) * Oral bioavailability (AUCpo/AUCiv) |
Countries
Norway
Outcome results
None listed